Three Core Cryo Symptoms: Meltzer’s Triad

Meltzer’s Triad

In 1956 Meltzer and Franklin described arthralgia, purpura and weakness as the three core symptoms of essential cryoglobulinemia. These are generally seen in people who have type II and type III cryoglobulinemia. It is seen in 25-30% of patients with cryo. I just thought I’d share this.